- Dry Eye
- Macular Deg
Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants
The authors present strong evidence that mitochondrial complex I defects are the major source of oxidative stress in TM cells of patients with POAG. Antioxidants such as Vit E and NAC are likely candidates to reduce ROS production and as complementary agents in the treatment of glaucoma.
The role of free radical-induced lipid oxidation in the development of cataracts in human and canine eyes
Free radical-induced lipid oxidation causes accumulation of lenticular lipid peroxidation (LPO) products. Lens opacity correlates with the level of the LPO accumulation. Oxidation of lens proteins is due to a decreased glutathione concentration in the lens.
Treatment with 1% N-acetylcarnosine (NAC) protects telomeres to prevent and dissolve mature cataracts in dogs.
Cataracts in small animals are caused by oxidative stress on lens epithelial cells. Treatment with 1% N-acetylcarnosine (NAC) releases L-carnosine ophthalmically, stabilizing telomeres to help prevent and dissolve mature cataracts in dogs.
Clinical impact of inflammation in dry eye disease
We now have a clearer understanding of the inflammatory processes involved in DED, and there is hope that the still emerging preclinical/clinical findings will be translated into new and highly effective therapies for patients in the near future.
In study 90.0% of the eyes treated with N-acetylcarnosine, 1% sol (NAC) showed a gradual improvement in b/c VA to 7-100%
Statistical analysis revealed the significant differences over 6 and 24 months in cumulative positive changes of overall characteristics of cataracts in the NAC-treated Group II from the control Group I.
Independent Study finds specific Amino Acids and Anti-Oxidants provide targeted support for those who suffer from IOP and Glaucoma.
This independent study finds that the antioxidants vitamin E and N-acetyl cysteine (NAC) may reduce the progression of glaucoma. Additionally noted is that effectively reducing or even reversing oxidation may …