The wise choice for your eyes… since 2007

ARMeD™ Retinal Support

$43.49 or $41.32 every 2 months

The bonded melatonin formula, when taken nightly, was found in studies to:

  • protect the retinal epithelium from oxidative damage
  • restore optimal circadian rhythms resulting in improved repair response in the eyes
  • act as a powerful balancing agent for the endocrine system.
  • regulates the amount of UV light delivered to the photo-receptors
  • (2 month supply) 1 box @ $43.49/box
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  • (6 month + supply) 3+ boxes @ 33.49/box = 23% Savings!

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ARMeD™ is a unique bonded Melatonin formula designed to reproduce the behavior of the youthful pineal gland in the human body. This unique Melatonin formula is optimized with highly specific excipients, to carefully mimic the body’s natural and optimal night peak release of Melatonin.

Extensive animal and human research has shown that when the correct circadian rhythm is attained, healing and repair responses in the body are enhanced. The ARMeD™ Bonded Melatonin formula, based on breakthrough clinical research targeting Macular Degeneration, offers a surprising new ocular benefit.

Note: Keep in cool dark conditions, out of the reach of children. Use before end of expiry date. Not for use by pregnant or lactating women. Disclaimer: This product and its statements have not been evaluated by the FDA. This product is not intended to treat, cure or prevent any disease.
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Safe & Effective Ingredients

ARMeD™ Retinal Repair formula contains a Melatonin from organic, plant-based ingredients and is uniquely bonded with Selenium and Zinc. It helps regulate immunological hormone functions to improve retinal healing and repair.

Clinically Proven Results

  1. 93% had arrested or improved their ARMD condition
  2. 54% of patients reported lessening of glare, reduced dryness, and improved clarity and comfort
  3. 78% reported sleep improvement and overall improved well-being

At the end of the study the majority exhibited reduced macular decline with zero side effects noted.

Enhancing the Eye's Restorative Properties

Restores the body’s youthful night-peak release of Melatonin. This bonded melatonin formula, when taken nightly, was found to re-establish optimal circadian rhythms, resulting in retinal healing and repair, as well as protecting the retinal epithelium from oxidative damage.

Directions:

Take 1 tablet before bedtime, ideally between 10PM and 11PM.

Bonded Organic Melatonin reverses AMD!

“Within 6 months 93% of patients had arrested or improved their ARMD condition, (both wet and dry). The improvements continued until the trial ended at 24 months.”

The control study

Effects of melatonin in age-related macular degeneration. Ann N Y Acad Sci. 2005 Dec;1057:384-92.. Yi C, Pan X, Yan H, Guo M, Pierpaoli W. Department of Fundus Diseases, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 510060 Guangzhou, China: Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16399908

The study included 55 to 100 patients with both wet and dry macular degeneration for a period of 6 months, with two years of follow up exams. The participants were given a, patented, formulation, now called, ARMeD™ to learn if a healing response was possible.

  • 100 patients with both wet and dry ARMD were given one tablet nightly at bedtime and monitored for 6 months
  • Subjects took 3mg of the bonded melatonin formula nightly, at bedtime
  • The age of patients were 55 to 82, the average age being 71
  • Approximately two thirds were men
  • Patients were evaluated, including actual fundus pictures taken at the beginning and at every 2-months thereafter,
  • 15 patients had diabetes; 11 had received cataract operations; 32 had some degree of senile cataract; 3 had received laser treatment; none had received any form of ARMD treatment.

Dr. Changxian Yi stated; “Our purpose was to explore a new approach to prevent and/or treat ARMD.” The study was also monitored by, world renowned endocrine specialist and melatonin expert, Dr. Walter Pierpaoli.

In the beginning, Dr. Changxian Yi’s theory was that a specific combination of melatonin, selenium and zinc would have the capacity to control eye pigmentation and thereby regulate the amount of light reaching the photoreceptors in the eye. The unique nutrient combination in the tablets would also scavenge hydroxyradicals and help to protect retinal pigment epithelium cells from oxidative/free radical damage which is considered to be a precursor to ARMD.

Results After 2-3 months:

The patients were then evaluated at regular periods and the initial results were dramatic, at 2-3 months of treatment the visual acuity had been stabilized, no further degeneration had occurred. A significant step toward helping those who suffer with this disease, but that was just the beginning…

Results After first 6 months:
  • 93% of patients have arrested or improved their ARMD condition,
  • 54% of patients report additional ophthalmic improvements,
  • 78% of patients had varying levels of sleep improvement and general overall improved feeling of well being,
  • 0% felt worse during treatment and no side effects were noted,.
  • This recent study suggests that more than 90% of patients can benefit within a 6 month period.

At the end of the study the vast majority had dramatically reduced pathologic macular changes. Additionally the patients reported better vision with improvements to glare, dryness, clarity and comfort.

For the trial participants, who continued past 6 months onto 12-months of nightly use, the changes in their fundus pictures were remarkable, (please note the before and after eye pictures presented within this article in figures 1-3).

Figure 1

image_a

Figure 1: The left slide shows the eye of a 67 year old male before treatment, his vision has been deteriorating for 2 years. The right picture shows the same eye 2 months later after ingestion of one tablet every night at bed time. He now has stable visual acuity of 0.3 with remarkable improvements in sub-retinal macular hemorrhage. In this study of 100 patients, 90% had, to varying degrees, regressed or reversed their ARMD within the first 6 monthsSource: Changxian Yi et al, effects of melatonin in age-related macular degeneration, Ann NY Acad Sci, 1057:384-392,2005


Figure 2

image_b

Figure 2: The left slide shows the eye of a 71-year old female with ARMD who after 6-months had her vision improve from 0.2 to 0.4 (as indicated in the right slide).


 Figure 3

image_c

Figure 3: A 58 year old male whose visual acuity at the start (left slide) was 0.2. This improved to 0.4 after 6-months of regular use. The sub-retinal hemorrhage and exudates was remarkably absorbed.


The study authors stated “Melatonin has been shown to have the capacity to control eye pigmentation and thereby regulate the amount of light reaching the photoreceptors, to scavenge hydroxyradicals and to protect retinal pigment epithelium (RPE) cells from oxidative damage. Therefore, it is reasonable to think that the physiological decrease of melatonin in aged people may be an important factor in RPE dysfunction

Powerful bonded Melatonin formula works to protect eyes from Glaucoma via three pathways:
  1. By controlling the eye pigmentation

    Eye pigmentation regulates the amount of UV light reaching the photoreceptors of the eyes. The macular pigment contributes to the protection of the retinal cells from free radicals caused by stress and the sun’s UV radiation.

  2. By preventing cell damage

    Melatonin provides powerful antioxidant protection for the tissues of the eyes, safeguarding the retinal epithelium (RPE) from oxidative damage. Clinical studies have shown that it may have a promising role in the safe treatment and management of Glaucoma.

  3. By facilitating the body’s natural healing process

    Melatonin improves the body’s natural and optimal night-peak release of Melatonin. This bonded melatonin formula, when taken nightly, was found to re-establish optimal circadian rhythms, resulting in healing and repair response in the eyes.

The Science Behind the Ingredients

Melatonin

According to clinical studies, Melatonin, being an efficient antioxidant with antinitridergic properties, has a promising role in the treatment and management of glaucoma. These same potent antioxidant properties could also protect the tissues of the eye against Age-Related Macular Degeneration, Cataracts, Glaucoma and other disorders.(1)

  1. Per O Lundmark, S R Pandi-Perumal, et al. Melatonin in the Eye: Implications for Glaucoma. Exp Eye Res. 2007 Jun;84(6):1021-30. https://pubmed.ncbi.nlm.nih.gov/17174303
Zinc

Zinc is vital to keeping your eyes healthy and vision sharp. Zinc is concentrated in a part of the retina called the “macula” and helps Vitamin A produce melanin, a pigment which has a protective effect on the eye. A deficiency in zinc has been associated with reduced night vision, while supplementation with zinc has been shown to slow the rate of age-related macular degeneration due to its importance in maintaining a healthy macula.(1) Zinc has also been shown to reduce cataracts by as much as 36% in people ages 65-74.(2)

Research has shown that zinc can correct age-related immuno-depression and several other hormonal and metabolic changes. It has been found that the low zinc levels in aging animals can be restored to normal values with either nocturnal administration of melatonin or transplantation of the pineal gland from young into older animals. Zinc is an essential component of more than 200 enzymes and one of the most relevant trace elements in the body. It is thus clear that additional zinc must be supplemented daily, in order that melatonin can better exert its anti-aging activities on the entire hormonal and immune systems! This important and novel scientific observation of the powerful anti-aging and immuno-enhancing activity of the combination of zinc and melatonin has contributed to the development of ARMeD™ which was proven effective in the clinical trials.

  1. Blasiak J, et al. Zinc and Autophagy in Age-Related Macular Degeneration. Int J Mol Sci. 2020 Jul; 21(14): 4994. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404247
  2. Sperduto R D, et al. The Linxian cataract studies. Two nutrition intervention trials. Arch Ophthalmol. 1993 Sep;111(9):1246-53. https://pubmed.ncbi.nlm.nih.gov/8363468
Selenium

Selenium is essential for the enzymatic reaction responsible for the synthesis of glutathione, a powerful physiological molecule which constantly protects the body from oxidative damage. A lack of selenium will thus result in a loss of the detoxification capacity of the body, immuno-depression and onset of degenerative diseases such as cancer.

Selenium, a mineral and antioxidant found naturally in foods like Brazil nuts, can reduce the risk of developing macular degeneration and act as a strong antioxidant for eye protection.(1) Selenium, when combined with Melatonin, also may help decrease levels of toxic MDA while significantly increasing levels of the powerful antioxidant Glutathione.(2)

  1. Hock Eng Khoo, Hui Suan Ng, et al. Nutrients for Prevention of Macular Degeneration and Eye-Related Diseases. Antioxidants (Basel). 2019 Apr; 8(4): 85. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523787
  2. Hande Hüsniye Telek. Effects of Selenium and Melatonin on Ocular Ischemic Syndrome. Biomed Res Int. 2019; 2019: 8080564. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925799

Dr. Pierpaoli’s views

Dr. Walter Pierpaoli

When asked about this recent finding, Dr. Pierpaoli stated; “Many people are aware of melatonin’s role in jet-lag, or as a potent antioxidant. Our research with this particular synergistic combination has highlighted its ability to re-synchronize the endocrine system as well as circadian rhythms of the wake-sleep cycles.

I note that while much has been discussed about the amazing ability of melatonin to, control eye pigmentation, regulate the amount of light reaching the photoreceptors and other functions in relation to eye structure; I surmise that the rebalancing of hormones and improvement of repair functions through the improved circadian sleep cycles are equally significant factors pointing to this formula’s ability to favorably impact both wet and dry age related macular degeneration as well as Glaucoma.

Dr. Pierpaoli went on to say; “We’ve seen many miraculous reversals of diseases in our patients with this formula. This latest study showing that it can even reverse age-related macular degeneration is truly a breakthrough in treating this condition.

Asked whether there may be further studies targeting ARMD and melatonin, Dr. Pierpaoli said; “We accept that additional studies are needed to further confirm these results, however we are delighted that a vital benefit to slow, halt and even reverse ARMD has been discovered. Whatever the outcome of further research into these pathways and actions, the fact remains that thousands, even millions of people can now benefit from this research to protect their vision.

References:

  1. Effects of melatonin in age-related macular degeneration. Yi C, Pan X, Yan H, Guo M, Pierpaoli W. Department of Fundus Diseases, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 510060 Guangzhou, China: www.ncbi.nlm.nih.gov/pubmed/16399908
  2. Changxian Yi et al, effects of melatonin in age-related macular degeneration, Ann NY Acad Sci, 1057:384- 392,2005
  3. Pierpaoli, W. and Regelson W. with Carol Colman, “The Melatonin Miracle”, Simon & Schuster, New York, 1995.
  4. Pierpaoli, W. The pineal gland: a circadian or a seasonal aging clock? Aging 3: 99-101, 1991.
  5. Pierpaoli, W. Dall’Ara, A, Pedrinis, E. and Regelson, W. The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice. Second Stromboli Conference on Aging and Cancer, June 1990. Ann. N.Y. Acad. Sci. 621: 291-313, 1991.
  6. Pierpaoli, W., and Lesnikov, V.A. The pineal aging clock. Evidence, models, mechanisms, interventions. The Aging Clock. Third Stromboli Conference on Aging and Cancer, June 1993. Ann. N.Y. Acad. Sci. 719: 461-473, 1994.
  7. Pierpaoli, W. and Regelson, W. Pineal control of aging: effect of melatonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. USA, 94: 787-791, 1994.
  8. Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A., Muzzioli, M., Pierpaoli, W. and Fabris, N. The immuno-reconstituting effect of melatonin or pineal grafting and its relation to zinc pool in aging mice. J. Neuroimmunol. 53: 189-201, 1994.
  9. Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A., Muzzioli, M., Lesnikov, V., Pierpaoli, W. and Fabris, N. The zinc pool is involved in the immunoreconstituting effect of melatonin in pinealectomized mice. J. Pharmac. & Exp. Therap. 277: 1200-1208, 1996.
  10. Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A., Pierpaoli, W. and Fabris, N. The zinc-melatonin interrelationship. A working hypothesis. The Aging Clock. Third Stromboli Conference on Aging and Cancer, June 1993. Ann. N.Y. Acad. Sci. 719: 298-307. 1994.
  11. Fabris, N. Neuroendocrine-immune aging: an integrative view on the role of zinc. The Aging Clock. Third Stromboli Conference on Aging and Cancer, June 1993. Ann. N.Y. Acad. Sci.719: 353-368, 1994.
  12. Meister, A. and Anderson, M.E. Glutathione. Ann. Rev. Biochem. 52: 711-760, 1983.

The Science Behind the Ingredients

ARMeD™ Advanced Retinal Support formula is based on published research conducted by Changxian Yi et al, – titled “Effects of melatonin in age-related macular degeneration”, Ann NY Acad Sci, 1057:384-392,2005 with assistance from the world renowned endocrine specialist and melatonin expert, Dr. Walter Pierpaoli.

Dr. Changxian Yi’s theory was that a specific combination of melatonin, selenium and zinc would have the capacity to control eye pigmentation and thereby regulate the amount of light reaching the photoreceptors in the eye. The unique nutrient combination in the tablets would also scavenge hydroxyradicals and help to protect retinal pigment epithelium cells from oxidative/free radical damage which is considered to be a precursor to ARMD.

For the trial participants, who continued past 6 months onto 12-months of nightly use, the changes in their fundus pictures were remarkable. [Learn More]

ARMeD™ combines, in a unique synergistic formula, three fundamental anti-aging molecules, where melatonin ultimately plays the master role for reactivation and restoration of our circadian rhythm to juvenile levels, resulting in normalization of all measurable immunological and endocrine functions. The age-postponing, metabolic and immunological effects of ARMeD™ can be easily measured by means of a normal periodic check-up.

The ARMeD™ formula contains a unique melatonin from organic, pharmaceutical grade, plant based, ingredients bonded with selenium and zinc. To ensure optimal healing and repair responses, critical excipients work with the bonded melatonin to regulate fundamental immunological hormone functions to a much greater degree.

Please note that ARMeD™ is quite distinct from the sublingual and time-released versions of melatonin supplements in the market place which have a pre-set time of melatonin release. ARMeD™ with bonded melatonin actually mimics nature by improving upon the body’s natural and optimal night peak release of melatonin and the results of this superior action speak for themselves. Take one tablet, each night, before bed time.

Melatonin

According to clinical studies, Melatonin, being an efficient antioxidant with antinitridergic properties, has a promising role in the treatment and management of glaucoma. These same potent antioxidant properties could also protect the tissues of the eye against Age-Related Macular Degeneration, Cataracts, and other disorders.(1)

  1. Per O Lundmark, S R Pandi-Perumal, et al. Melatonin in the Eye: Implications for Glaucoma. Exp Eye Res. 2007 Jun;84(6):1021-30. https://pubmed.ncbi.nlm.nih.gov/17174303
Zinc

Zinc is vital to keeping your eyes healthy and vision sharp. Zinc is concentrated in a part of the retina called the “macula” and helps Vitamin A produce melanin, a pigment which has a protective effect on the eye. A deficiency in zinc has been associated with reduced night vision, while supplementation with zinc has been shown to slow the rate of age-related macular degeneration due to its importance in maintaining a healthy macula.(1) Zinc has also been shown to reduce cataracts by as much as 36% in people ages 65-74.(2)

Research has shown that zinc can correct age-related immuno-depression and several other hormonal and metabolic changes. It has been found that the low zinc levels in aging animals can be restored to normal values with either nocturnal administration of melatonin or transplantation of the pineal gland from young into older animals. Zinc is an essential component of more than 200 enzymes and one of the most relevant trace elements in the body. It is thus clear that additional zinc must be supplemented daily, in order that melatonin can better exert its anti-aging activities on the entire hormonal and immune systems! This important and novel scientific observation of the powerful anti-aging and immuno-enhancing activity of the combination of zinc and melatonin has contributed to the development of ARMeD™ which was proven effective in the clinical trials.

  1. Blasiak J, et al. Zinc and Autophagy in Age-Related Macular Degeneration. Int J Mol Sci. 2020 Jul; 21(14): 4994. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404247
  2. Sperduto R D, et al. The Linxian cataract studies. Two nutrition intervention trials. Arch Ophthalmol. 1993 Sep;111(9):1246-53. https://pubmed.ncbi.nlm.nih.gov/8363468
Selenium

Selenium is essential for the enzymatic reaction responsible for the synthesis of glutathione, a powerful physiological molecule which constantly protects the body from oxidative damage. A lack of selenium will thus result in a loss of the detoxification capacity of the body, immuno-depression and onset of degenerative diseases such as cancer.

Selenium, a mineral and antioxidant found naturally in foods like Brazil nuts, can reduce the risk of developing macular degeneration and act as a strong antioxidant for eye protection.(1) Selenium, when combined with Melatonin, also may help decrease levels of toxic MDA while significantly increasing levels of the powerful antioxidant Glutathione.(2)

  1. Hock Eng Khoo, Hui Suan Ng, et al. Nutrients for Prevention of Macular Degeneration and Eye-Related Diseases. Antioxidants (Basel). 2019 Apr; 8(4): 85. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523787
  2. Hande Hüsniye Telek. Effects of Selenium and Melatonin on Ocular Ischemic Syndrome. Biomed Res Int. 2019; 2019: 8080564. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925799

Note: ARMeD™ should not be taken during pregnancy or while nursing. Alcohol, NSAIDS (anti-inflammatory medications) or beta-blockers may inhibit the benefits of Melatonin.

CLINICAL STUDY

Mechanisms for countering oxidative stress and damage in retinal pigment epithelium

Study: Mechanisms for countering oxidative stress and damage in retinal pigment epithelium
Publication: Int Rev Cell Mol Biol . 2012;298:135-77. doi: 10.1016/B978-0-12-394309-5.00004-3.
Date published: February 3, 2022
Authors: Scott M Plafker, Gary B O’Mealey, Luke I Szweda
Summary: Clinical and experimental evidence supports that chronic oxidative stress is a primary contributing factor to numerous retinal degenerative diseases, such as age-related macular degeneration (AMD). Eyes obtained postmortem from AMD patients have extensive free radical damage to the proteins, lipids, DNA, and mitochondria of their retinal pigment epithelial (RPE) cells. In addition, several mouse models of chronic oxidative stress develop many of the pathological hallmarks of AMD. However, the extent to which oxidative stress is an etiologic component versus its involvement in disease progression remains a major unanswered question. Further, whether the primary target of oxidative stress and damage is photoreceptors or RPE cells, or both, is still unclear. In this review, we discuss the major functions of RPE cells with an emphasis on the oxidative challenges these cells encounter and the endogenous antioxidant mechanisms employed to neutralize the deleterious effects that such stresses can elicit if left unchecked.

CLINICAL STUDY

Potential of melatonin to treat or prevent age-related macular degeneration through stimulation of telomerase activity

Study: Potential of melatonin to treat or prevent age-related macular degeneration through stimulation of telomerase activity
Publication: Med Hypotheses . 2011 Jan;76(1):79-85. doi: 10.1016/j.mehy.2010.08.036. Epub 2010 Sep 29.
Date published: February 2, 2022
Authors: Reza Rastmanesh
Summary: Melatonin may play a causal role in the occurrence of age-related macular degeneration (AMD). Replicative capacity and response to injury in the retinal pigment epithelium (RPE) is compromised during aging. Prevention of telomere shortening by antioxidants may be a useful approach for reducing the cumulative effects of oxidative stress in RPE cells. Melatonin, a well known antioxidant, which acts advantageously as an amphiphilic agent, may benefit AMD patients more than commonly used lipophilic or hydrophilic antioxidants. It also may act through mechanisms other than antioxidant mechanisms because melatonin has receptors localized in the RPE, which act locally as a neurohormone and/or neuromodulator. Results of a clinical trial showed that 3mg melatonin given orally each night at bedtime for 3 months to AMD patients reduced pathologic macular changes. I hypothesize that melatonin exerts additional benefit through down-regulating hTERT (catalytic subunit if telomerase) expression and stimulated telomerase activity in RPE, which subsequently helps to prevent or treat AMD. I suggest that melatonin therapy as pharmacologic agents and/or melatonin-rich foods, especially in AMD patients with measured low serum melatonin levels or high risk patients would be possibly an alternative approach to prevent and/or treat AMD. I suggest that melatonin has potential to prevent telomere shortening in RPE, while not precluding other mechanisms, namely antioxidative properties and/or restoration of inner blood-retina barrier (iBRB) integrity, reduced vascular endothelial growth factor (VEGF) and nitric oxide (NO) levels as well as leakage of horseradish peroxidase (HRP), inhibiting hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization under hypoxia.

Bundles containing ARMeD™ Retinal Support