New Breakthrough for Age-Related Macular Degeneration
ARMeD™ Advanced Retinal Support formula is based on published research conducted by Changxian Yi et al, – titled “Effects of melatonin in age-related macular degeneration”, Ann NY Acad Sci, 1057:384-392,2005 with assistance from the world renowned endrocrin specialist Dr. Walter Pierpaoli. The ARMeD™ formula contains a unique melatonin from organic, pharmaceutical grade, plant based, ingredients bonded with selenium and zinc. To ensure optimal healing and repair responses, critical excipients work with the bonded melatonin to regulate fundamental immunological hormone functions to a much greater degree. Please note that ARMeD™ is quite distinct from the sublingual and time-released versions of melatonin supplements in the market place which have a pre-set time of melatonin release. ARMeD™ with bonded melatonin actually mimics nature by improving upon the body’s natural and optimal night peak release of melatonin and the results of this superior action speak for themselves. Take one tablet, each night, before bed time.
The bonded melatonin formula, when taken nightly, was found to;
- re-establish optimal circadian rhythms resulting in healing and repair response in the eyes,
- control eye pigmentation thereby regulating the amount of UV light delivered to the photo-receptors of the eyes,
- protect the retinal epithelium (RPE) from oxidative damage,
- and act as a powerful balancing agent for the endocrine system.
Ingredients: Pharmaceutical grade Melatonin (3 mg), bonded with Zinc (8.7mg), and Selenium (50 mcg). Excipients: Avicel, Mannitol, Povidonum and Magnesium Stearate.
Directions: Take one tablet before bedtime.
Within 6 months 90% of the trial participants had improved their AMD condition.
The improvements continued until the trial ended at 24 months.
Figure 1 – – Before and after fundus pics were taken of all trial participants. Complete Study Overview Figure 1: The left slide shows the eye of a 67 year old male before treatment, his vision has been deteriorating for 2 years. The right picture shows the same eye 2 months later after ingestion of the bonded melatonin tablet every night at bed time. He now has stable visual acuity of 0.3 with remarkable improvements in sub-retinal macular hemorrhage. In this study of 100 patients, 90% of them had regressed or reversed their ARMD within 6 months. Source: Changxian Yi et al, effects of melatonin in age-related macular degeneration, Ann NY Acad Sci, 1057:384-392,2005
The before and after fundus pictures were remarkable! – clinical results
Additionally, the trial participants reported; lessoning of glare, reduced dryness, and improved clarity and comfort. Dr. Changxian Yi stated; “Our purpose was to explore a new and safe approach to prevent or even treat ARMD and we found so much more..”
- Ann N Y Acad Sci. 2005 Dec;1057:384-92. Effects of melatonin in age-related macular degeneration. Yi C, Pan X, Yan H, Guo M, Pierpaoli W. Department of Fundus Diseases, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 510060 Guangzhou, China: Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16399908
- Pierpaoli, W. and Regelson W. with Carol Colman, “The Melatonin Miracle”, Simon & Schuster, New York, 1995.
- Pierpaoli, W. The pineal gland: a circadian or a seasonal aging clock? Aging 3: 99-101, 1991.
- Pierpaoli, W. Dall’Ara, A, Pedrinis, E. and Regelson, W. The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice. Second Stromboli Conference on Aging and Cancer, June 1990. Ann. N.Y. Acad. Sci. 621: 291-313, 1991.
- Pierpaoli, W., and Lesnikov, V.A. The pineal aging clock. Evidence, models, mechanisms, interventions. The Aging Clock. Third Stromboli Conference on Aging and Cancer, June 1993. Ann. N.Y. Acad. Sci. 719: 461-473, 1994.
- Pierpaoli, W. and Regelson, W. Pineal control of aging: effect of melatonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. USA, 94: 787-791, 1994.
- Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A., Muzzioli, M., Pierpaoli, W. and Fabris, N. The immuno-reconstituting effect of melatonin or pineal grafting and its relation to zinc pool in aging mice. J. Neuroimmunol. 53: 189-201, 1994.
- Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A., Muzzioli, M., Lesnikov, V., Pierpaoli, W. and Fabris, N. The zinc pool is involved in the immunoreconstituting effect of melatonin in pinealectomized mice. J. Pharmac. & Exp. Therap. 277: 1200-1208, 1996.
- Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A., Pierpaoli, W. and Fabris, N. The zinc-melatonin interrelationship. A working hypothesis. The Aging Clock. Third Stromboli Conference on Aging and Cancer, June 1993. Ann. N.Y. Acad. Sci. 719: 298-307. 1994.
- Fabris, N. Neuroendocrine-immune aging: an integrative view on the role of zinc. The Aging Clock. Third Stromboli Conference on Aging and Cancer, June 1993. Ann. N.Y. Acad. Sci.719: 353-368, 1994.
- Meister, A. and Anderson, M.E. Glutathione. Ann. Rev. Biochem. 52: 711-760, 1983.
New Hope for Macular Degeneration
The study was monitored by world renowned endocrine specialist and melatonin expert Walter Pierpaoli MD, PhD. who was also responsible for the refinement of the bonded melatonin formulation used in the trial. DR. Walter Pierpaoli is director of the Jean Choay Institute for Biomedicals Research, Switzerland and President of the Interbion Foundation in Switzerland, specializing in immunology, endocrinology, neuropeptides and aging. Author of over 130 publications on referenced scientific journals organizer of the Stromboli Conferences on Aging and Cancer. Author of New York Times bestseller; “Melatonin Miracle” which has been translated into 15 languages. Author of “The key of life” regarding the impact of proper use of melatonin. His research findings were paramount to the development of the current Neuroendocrine Theory of Aging. Based on Dr. Pierpaoli’s research, ARMeD™ contains a pharmaceutical grade melatonin which is bonded with selenium and zinc along with critical excipients that work synergistically to optimize fundamental immunological hormone functions to a much greater degree.
A plant derived product: ARMeD™ is produced by synthesis from pharmaceutical grade organic plant based ingredients, starting from serotonin that is actually extracted from organic coffee beans, and is molecularly identical to the melatonin produced in the human body. Containing the highest pharmaceutical grade of melatonin available; each tablet has been scientifically tested for biological activity and chemical purity.
Why the Zinc? Research has shown that zinc can correct age related immunodepression and several other hormonal and metabolic changes. It has been found that the low zinc levels in aging animals can be restored to normal values with either nocturnal administration of melatonin or transplantation of the pineal gland from young into older animals. Zinc is an essential component of more than 200 enzymes and one of the most relevant trace elements in the body. It is thus clear that additional zinc must be supplemented daily, in order that melatonin can better exert its anti-aging activities on the entire hormonal and immune systems! This important and novel scientific observation of the powerful anti-aging and immuno-enhancing activity of the combination of zinc and melatonin has contributed to the development of the ARMeD™ formula.
Why the selenium? Selenium is essential for the enzymatic reaction responsible for the synthesis of glutathione, a powerful physiological molecule which constantly protects the body from oxidative damage. A lack of selenium will thus result in a loss of the detoxification capacity of the body, immuno-depression and onset of degenerative diseases such as cancer. ARMeD™ combines, in a unique synergistic formula, three fundamental anti-aging molecules, where melatonin ultimately plays the master role for reactivation and restoration of our circadian rhythm to juvenile levels, resulting in normalization of all measurable immunological and endocrine functions. The age-postponing, metabolic and immunological effects of ARMeD™ can be easily measured by means of a normal periodic check-up.
NOTE: Many of our customers who purchased ARMeD™ also purchased Can-C™ eye drops with N-acetyl-carnosine and Can-C Plus™ capsules with N-acetyl-cystein, to further support the over all health environment of their eyes. All three products when taken together provide powerful antioxidant protection for the eyes…