June is Cataract Awareness Month - click here for FREE healthy vision tips
June is Cataract Awareness Month - click here for FREE healthy vision tips
Macular Degeneration is an eye disease associated with aging; it causes central vision loss due to damage to a part of the retina called the “macula”. Dry Macular Degeneration is a deterioration of the center of the retina. Wet Macular Degeneration is caused by leaky blood vessels growing under the retina. Macular Degeneration is the leading cause of vision loss among the aging population.
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1 Package of Can-C™ Eye Drops
1 Package of Nac-C™ Plus Capsules
1 Package of ARMeD™ Advanced Ocular Support
ARMeD Directions:
Take 1 tablet before bedtime, ideally between 10PM and 11PM.
Can-C™ eye drops initial loading dose: two drops applied in the morning to each eye (4 drops total) and two drops in the evening to each eye (4 drops total).
Can-C™ eye drops maintenance dose (general eye health support and prevention): After 3 to 6 months of use you will only need to use 1-2 drops of Can-C™ in each eye daily, with a one week pause from use every two months. The product will last a very long time at this level of usage.
Nac-C Plus™ Capsules dose: take 2 capsules daily Nac-C Plus™ Capsules. When used in conjunction with Can-C™ eye drops, Nac-C Plus capsules increase the length of time that Can-C™ eye drops stay active in the eye by inhibiting the breakdown of the L-carnosine that has been topically administered through the drops. This sustained effect significantly enhances free radical protection and decreases the oxidative environment within the eye, allowing for a faster healing response.
Independent clinical results are based on consistent daily use.
“Within 6 months 93% of patients had arrested or improved their ARMD condition, (both wet and dry). The improvements continued until the trial ended at 24 months.”
Effects of melatonin in age-related macular degeneration. Ann N Y Acad Sci. 2005 Dec;1057:384-92.. Yi C, Pan X, Yan H, Guo M, Pierpaoli W. Department of Fundus Diseases, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 510060 Guangzhou, China: Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16399908
The study included 55 to 100 patients with both wet and dry macular degeneration for a period of 6 months, with two years of follow up exams. The participants were given a, patented, formulation, now called, ARMeD™ to learn if a healing response was possible.
Dr. Changxian Yi stated; “Our purpose was to explore a new approach to prevent and/or treat ARMD.” The study was also monitored by, world renowned endocrine specialist and melatonin expert, Dr. Walter Pierpaoli.
In the beginning, Dr. Changxian Yi’s theory was that a specific combination of melatonin, selenium and zinc would have the capacity to control eye pigmentation and thereby regulate the amount of light reaching the photoreceptors in the eye. The unique nutrient combination in the tablets would also scavenge hydroxyradicals and help to protect retinal pigment epithelium cells from oxidative/free radical damage which is considered to be a precursor to ARMD.
The patients were then evaluated at regular periods and the initial results were dramatic, at 2-3 months of treatment the visual acuity had been stabilized, no further degeneration had occurred. A significant step toward helping those who suffer with this disease, but that was just the beginning…
At the end of the study the vast majority had dramatically reduced pathologic macular changes. Additionally the patients reported better vision with improvements to glare, dryness, clarity and comfort.
For the trial participants, who continued past 6 months onto 12-months of nightly use, the changes in their fundus pictures were remarkable, (please note the before and after eye pictures presented within this article in figures 1-3).
Figure 1
Figure 1: The left slide shows the eye of a 67 year old male before treatment, his vision has been deteriorating for 2 years. The right picture shows the same eye 2 months later after ingestion of one tablet every night at bed time. He now has stable visual acuity of 0.3 with remarkable improvements in sub-retinal macular hemorrhage. In this study of 100 patients, 90% had, to varying degrees, regressed or reversed their ARMD within the first 6 monthsSource: Changxian Yi et al, effects of melatonin in age-related macular degeneration, Ann NY Acad Sci, 1057:384-392,2005
Figure 2
Figure 2: The left slide shows the eye of a 71-year old female with ARMD who after 6-months had her vision improve from 0.2 to 0.4 (as indicated in the right slide).
Figure 3
Figure 3: A 58 year old male whose visual acuity at the start (left slide) was 0.2. This improved to 0.4 after 6-months of regular use. The sub-retinal hemorrhage and exudates was remarkably absorbed.
The study authors stated “Melatonin has been shown to have the capacity to control eye pigmentation and thereby regulate the amount of light reaching the photoreceptors, to scavenge hydroxyradicals and to protect retinal pigment epithelium (RPE) cells from oxidative damage. Therefore, it is reasonable to think that the physiological decrease of melatonin in aged people may be an important factor in RPE dysfunction”
Eye pigmentation regulates the amount of UV light reaching the photoreceptors of the eyes. The macular pigment contributes to the protection of the retinal cells from free radicals caused by stress and the sun’s UV radiation.
Melatonin provides powerful antioxidant protection for the tissues of the eyes, safeguarding the retinal epithelium (RPE) from oxidative damage. Clinical studies have shown that it may have a promising role in the safe treatment and management of Glaucoma.
Melatonin improves the body’s natural and optimal night-peak release of Melatonin. This bonded melatonin formula, when taken nightly, was found to re-establish optimal circadian rhythms, resulting in healing and repair response in the eyes.
According to clinical studies, Melatonin, being an efficient antioxidant with antinitridergic properties, has a promising role in the treatment and management of glaucoma. These same potent antioxidant properties could also protect the tissues of the eye against Age-Related Macular Degeneration, Cataracts, Glaucoma and other disorders.(1)
Zinc is vital to keeping your eyes healthy and vision sharp. Zinc is concentrated in a part of the retina called the “macula” and helps Vitamin A produce melanin, a pigment which has a protective effect on the eye. A deficiency in zinc has been associated with reduced night vision, while supplementation with zinc has been shown to slow the rate of age-related macular degeneration due to its importance in maintaining a healthy macula.(1) Zinc has also been shown to reduce cataracts by as much as 36% in people ages 65-74.(2)
Research has shown that zinc can correct age-related immuno-depression and several other hormonal and metabolic changes. It has been found that the low zinc levels in aging animals can be restored to normal values with either nocturnal administration of melatonin or transplantation of the pineal gland from young into older animals. Zinc is an essential component of more than 200 enzymes and one of the most relevant trace elements in the body. It is thus clear that additional zinc must be supplemented daily, in order that melatonin can better exert its anti-aging activities on the entire hormonal and immune systems! This important and novel scientific observation of the powerful anti-aging and immuno-enhancing activity of the combination of zinc and melatonin has contributed to the development of ARMeD™ which was proven effective in the clinical trials.
Selenium is essential for the enzymatic reaction responsible for the synthesis of glutathione, a powerful physiological molecule which constantly protects the body from oxidative damage. A lack of selenium will thus result in a loss of the detoxification capacity of the body, immuno-depression and onset of degenerative diseases such as cancer.
Selenium, a mineral and antioxidant found naturally in foods like Brazil nuts, can reduce the risk of developing macular degeneration and act as a strong antioxidant for eye protection.(1) Selenium, when combined with Melatonin, also may help decrease levels of toxic MDA while significantly increasing levels of the powerful antioxidant Glutathione.(2)
When asked about this recent finding, Dr. Pierpaoli stated; “Many people are aware of melatonin’s role in jet-lag, or as a potent antioxidant. Our research with this particular synergistic combination has highlighted its ability to re-synchronize the endocrine system as well as circadian rhythms of the wake-sleep cycles.
I note that while much has been discussed about the amazing ability of melatonin to, control eye pigmentation, regulate the amount of light reaching the photoreceptors and other functions in relation to eye structure; I surmise that the rebalancing of hormones and improvement of repair functions through the improved circadian sleep cycles are equally significant factors pointing to this formula’s ability to favorably impact both wet and dry age related macular degeneration as well as Glaucoma.”
Dr. Pierpaoli went on to say; “We’ve seen many miraculous reversals of diseases in our patients with this formula. This latest study showing that it can even reverse age-related macular degeneration is truly a breakthrough in treating this condition.”
Asked whether there may be further studies targeting ARMD and melatonin, Dr. Pierpaoli said; “We accept that additional studies are needed to further confirm these results, however we are delighted that a vital benefit to slow, halt and even reverse ARMD has been discovered. Whatever the outcome of further research into these pathways and actions, the fact remains that thousands, even millions of people can now benefit from this research to protect their vision.”
References:
Dr. Mark Babizhayev, a leading biophysicist in the area of natural peptides and their unique ability to reverse oxidation has developed and patented this specific oral formulation to effectively sustain the activity of Can-C eye drops for longer periods within the eye tissues.
When taken consistently with Can-C eye drops, Nac-C Plus increases the length of time that the Can-C eye drops remain active in the eye, by preventing and slowing the break down of carnosine once it has been topically delivered. This sustaining action greatly improves free radical protection and further reduces the oxidative environment within the eye allowing for an accelerated healing response.
We know that Can-C™ eye drops are highly effective on their own and are a stand alone product for the reversal of many ocular conditions. Nac-C Plus™ is a complementary supplement for those who want to maximize their effort with the use of Can-C™ eye drops. In addition, those who have more mature cataract with measurably diminished vision will greatly optimize their effort by taking Nac-C Plus in addition to their daily applications of Can-C™ eye-drops.
Nac-C Plus has been formulated, approved and patented by the inventors of the Can-C eye-drop technology. Designed to be used with Can-C eye-drops, Nac-C Plus™ taken orally helps to support the effectiveness and optimize the action of Can-C eye drops.
With the knowledge that there is a natural range of the histidyl dipeptides within mammalian tissues we have investigated possible synergism between them in respect of antioxidant activity in ophthalmic treatments.
Considering the efficacy of N-acetylcarnosine eye drops in the therapeutic treatment of ripe cataracts, we now theorize that, declining visual acuity, along with the onset of ‘halo’ effects and vitreous lesions, including floaters and even elevated IOP, may be a result of diminished Glutathione levels within the eye.
“New research supports the protective effect of vitamin E, N-acetylcysteine as well as mitochondrial permeability transition (MPT) inhibitors in the management POAG” Dr. Yuan He more information In a separate pilot study, ripe, human, age-related, cataract is significantly reversed over a period of 5 months, with the application of Can-C™ N-acetylcarnosine eye drops (2 drops twice daily) combined with Nac-C Plus™, 1 tablet (two times daily).
We found that the L-Histidine ingredient in the Nac-C Plus formulation acts synergistically with other natural imidazole containing Peptidomimetics (N-acetylcarnosine, L-carnosine) as antioxidants. Our results show that combining imidazole containing compounds at near physiological concentrations results in heightened synergistic anti-oxidant activity. The clinical and experimental data demonstrate the improved effectiveness and safety of the combined treatment modality.
The oral consumption of the N-acetyl-cysteine ingredient in Nac-C Plus, boosts reduced glutathione levels in the human crystalline lens. As indicated in the Figure 1, ripe age-related cataract is significantly reversed within 5 months of combined treatment.
Figure 1:
Left image: pronounced opacities in the lens layers prior cataract treatment;
Right image: An appearance of the rose reflex visible through the lens which became significantly more transparent after 5 months of combined treatment of cataract with the N-acetylcarnosine eye drop combined with the oral supplementation of Nac-C Plus.Conclusion: Manipulation with chemical chaperones; N-acetylcarnosine, carnosine, D- pantethine or regulated/inducible molecular chaperone protein function (such as alpha-crystallin chaperone activity in the lens) offers novel therapies for reversal of (ripe) cataracts, retinal degeneration and ocular complications of diabetes.
Other Ingredients: Micro-crystalline Cellulose, Di Basic Calcium Phosphate, Magnesium Stearate, Aerosil, Vegetarian Capsule.
Shown to reduce cataract risk, Vitamin E (AKA alpha-tocopherol) is a fat-soluble antioxidant found in the membranes and lens fibers of the eye. It is thought to reduce degradation of lens lipids and stabilize the cell membranes of the lens, thereby protecting against cataracts. Several studies have demonstrated that low vitamin E levels are associated with increased cataract risk(1) while higher vitamin E consumption protects against cataract formation.(2)
Zinc is vital to keeping your eyes healthy and vision sharp. Zinc is concentrated in a part of the retina called the “macula” and helps Vitamin A produce melanin, a pigment which has a protective effect on the eye. A deficiency in zinc has been associated with reduced night vision, while supplementation with zinc has been shown to slow the rate of age-related macular degeneration due to its importance in maintaining a healthy macula.(1) Zinc has also been shown to reduce cataracts by as much as 36% in people ages 65-74.(2)
Glutathione is especially concentrated in the lens of the eye, and when it is depleted due to aging or oxidative stress it can cause cataract formation.(1, 2) That’s because glutathione is key to protecting lens flexibility and clarity, acting as a very powerful antioxidant to shield proteins and enzymes from oxidative stress caused by free radicals.(3) That means glutathione is something we want more of. Orally-administered N-Acetyl-Cysteine supports the glutathione sparing effects of Can-C™ eye drops and further increases tissue glutathione levels in the eye.
L-Histidine works synergistically with L-Carnosine and N-Acetylcarnosine to create heightened antioxidant activity, thereby protecting the eye from cataract-causing damage.(1) Clinical trials have shown that adding L-Histidine to other “natural imidazole-containing Peptidomimetics” like the ones mentioned above leads to a demonstrable increase in the treatment’s effectiveness and safety.(2, 3)
Cataracts tend to result from oxidative stress, and L-Carnosine has been shown to have an antioxidant impact on a cataract-affected lens, enhancing DNA repair and helping to prevent DNA strand breaks caused by UV radiation.(1)
L-Carnosine has been shown in clinical trials to be highly effective at protecting against and/or reversing cataracts, improving vision and quality of life.(2, 3) In fact, according to a Chinese trial on 96 patients aged 60 or older, Carnosine has a significant effect on primary senile cataracts, with a 100% effective rate. The impact rate for mature senile cataracts was 80%.(4)
D-Pantethine works synergistically with N-Acetyl-Carnosine and L-Carnosine to help reverse cataracts, retinal degeneration, and ocular complications of diabetes.(1)
L-Methionine is an essential amino acid naturally synthesized in the body after protein consumption, and is a precursor to the creation of other amino acids that support eye health like taurine, carnitine, and cysteine. It is found naturally in egg whites, fish, poultry, and seaweed, among other foods.
When combined with adequate amounts of B vitamins, L-Methionine can help reduce homocysteine levels, relieving glaucoma, macular degeneration, and other retinal conditions, as well as detoxifying the body.(1, 2)
Nac-C Plus tablets previously named Can-C Plus, are now available in US and European Markets
Patents: (WO 2004/028536 A1; WO 94/19325; WO 95/12581; WO 2004/064866 A1)
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*Disclaimer: The above statements have not been evaluated by the FDA. They are not intended to diagnose, treat, cure or prevent any disease or condition.
If you have a health condition or concern, consult a physician or your alternative health care provider.
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