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CLINICAL STUDY

Study finds that Melatonin also offers a promising role in the safe treatment and management of Glaucoma

Study: Melatonin in the eye: implications for glaucoma.
Publication: Experimental eye Research, 14 Dec 2006, 84(6):1021-1030
Date published: January 16, 2022
Authors: Lundmark PO1, Pandi-Perumal SR, Srinivasan V, Cardinali DP, Rosenstein RE
Summary: Melatonin synthesis occurs in the retina of humans. In view that melatonin is a potent antioxidant molecule, it can be effective in scavenging free radicals that are generated in ocular tissues. By this mechanism melatonin could protect the ocular tissues against disorders like glaucoma, age-related macular degeneration, retinopathy of prematurity, photo-keratitis and cataracts. Although an increased intraocular pressure is an important risk factor in glaucoma, other concomitant phenomena like increased glutamate levels, altered nitric oxide metabolism and increased free radical generation seem to play a significant role in its pathogenesis.
“Data indicates that melatonin, being an efficient antioxidant with antinitridergic properties, has a promising role in the treatment and management of glaucoma.”

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