What is Can-C™?
The amino acid L-Carnosine is abundant in young healthy eyes. Researchers discovered that those with degenerative ocular illnesses like cataracts had become severely deficient in this very important ocular antioxidant. Topically applied Can-C™ eyedrops effectively re-establish optimal levels of this powerful antioxidant to the eye thereby generating healing and repair response in many sufferers.
The eyes’ innate ability to restore itself, manage inflammationand resist infection even after injury is one of its most impressive qualities. However when the eye’s natural L-Carnosine levels become deficient these powerful healing abilities are compromised. Can-C™ eye drops deliver a special ocular form of L-Carnosine called N-acetyl-Carnosine which quickly restores; oxidation management, DNA repair, hydration and pH balance all of which if left unchecked, lead to the most common degenerative eye conditions. Cataracts are induced by cross linking of proteins (Oxidation), and N-acetyl-Carnosine has been proven to have a powerful antioxidant effect on a cataract-affected lens, improving DNA repair and preventing DNA strand breaks caused by UV radiation.(2) When N-Acetyl-Carnosine is applied to the eye’s surface, it passes through the cornea into aall systems of the eye including the lens, where it is converted into L-Carnosine. As a result, administering NAC eye drops may help to slow or even stop the progression of cataracts, improving eyesight and quality of life.(3)
How do Can-C™eye drops work?
Can-C™ N-acetylcarnosine (NAC) eye drops have been shown to be a hugely impactful on eye health during clinical trials. When used as part of an eye care routine, they aid in the repair and recovery of the eye while enhancing clarity, glare sensitivity, color perception, and overall vision. They help to improve eye health and vision through a variety of mechanisms(1):
- When NAC penetrates the cornea, it metabolizes into the protein L-carnosine, preventing free radicals from inactivating antioxidants in lens cells.
- By competing for the glycating agent, L-carnosine reduces autooxidation of glycation reactions to the lens proteins, sparing the crystalline lens proteins from alteration.
- L-carnosine is a universal antioxidant that prevents oxidative stress and lens damage by scavenging lipid hydroperoxides, aldehydes, and oxygen radicals.
- L-carnosine activates proteasome activity in the lens, reversing cataract aggregation and restoring lens clarity.
What is Nac-C Plus™?
We know Can-C™ eye drops are highly effective on their own and can be used to treat a wide range of ocular disorders. For individuals who wish to get the most out of their Can-C™ eye drops, Nac-C Plus™ is a supplemental supplement. Furthermore, patients with more advanced cataracts and measurable vision loss will benefit considerably from taking Nac-C Plus™ in addition to their daily Can-C™ eye-drop administrations.
What do Nac-C Plus™ capsules do?
The creators of the Can-C™ eye-drop technology devised, approved, and patented the formula for Nac-C Plus™ capsules. Nac-C Plus™, when taken orally with Can-C™ eye drops, serves to support the effectiveness and optimize the action of the eye drops.
- Increases Can-C™ Eye Drops’ antioxidant activity and the amount of time they stay active in the eye.
- Provides multiple healing pathways due to the synergy between topically applied Can-C™ eye drops and the systemic effects of Nac-C Plus™ capsules.
- Elevate Glutathione levels to improve essential amino acid balance, further optimizing long term ocular healing and repair mechanisms.
How do Nac-C Plus™ Capsules work to enhance Can-C™ eye drops?
By inhibiting and reducing the breakdown of L-carnosine, Nac-C Plus™ improves the effectiveness of Can-C™ eye drops. Nac-C Plus™ greatly increases free radical protection and lowers the oxidative environment within the eye by increasing the duration of action of the drops in the eye, enabling an expedited healing response.
The ability of the eye to mend itself and resist infection after injury is one of its most impressive qualities. By protecting the lens of the eye from degradation, giving critical nutrients, improving DNA repair, and decreasing oxidative stress that could otherwise disrupt the natural healing process, Nac-C Plus™ Capsules work in unison with Can-C™ Eye Drops to support and expedite the healing process.
Clinically Proven Ingredient N-Acetyl-Carnosine (NAC)
Can-C™ contains a proprietary form of N-Acetyl-Carnosine, a highly specific intraocular form of Carnosine that works as a stabilizer and time-release carrier for the di-peptide L-Carnosine, securely transporting it into the aqueous humour of the eye when given topically. L-Carnosine becomes most active in its ability to operate as a natural and highly effective free radical scavenger in the fluid surrounding the lens, boosting DNA repair and helping to avoid DNA strand breaks induced by UV radiation.(7)
Clinical investigations have demonstrated that L-carnosine is highly effective for preventing and/or repairing cataracts and vision loss.(4, 5) Carnosine has a substantial impact on primary senile cataracts with a 100% success rate observed in a Chinese study of 96 patients aged 60 or older. For adult senile cataracts, the effect rate was 80%.(6)
N-Acetyl-Carnosine (NAC) has been proven in studies to enhance lens clarity in people and dogs with age-related cataracts, allowing previously cloudy areas to clear up and improve eyesight, as well as helping to prevent cataracts from developing in the first place.(1)
The biological activity and therapeutic efficacy of “carnosines” varies a lot depending on where they come from. For example, because of heavy metal salts, proteins, and other contaminants, extractions from meat muscle components can have low biological and antioxidant activity. Carnosine is difficult to purify since its biological and antioxidant capabilities are easily lost throughout the process.
Dr. Mark Babizhayev, inventor of Can-C™, demonstrated through his research that using non-approved N-Acetyl-Carnosine formulations will not help treat senile cataracts due to a lack of anti-cataract and antioxidant properties.
For safety and efficacy, you should only use proprietary Can-C™ brand N-Acetyl-Carnosine eye drops on your eyes. Before administering any Can-C™ eye drop product to the eyes, look for the certified Can-C™ hologram on the packaging.
After 6 months, placebo-controlled clinical studies demonstrated that in eyes treated with the specific purified N-Acetyl-Carnosine found in Can-C™ eye drops:
- 90% showed improvements in visual acuity.
- 89% saw improvement of glare sensitivity.
- 42% had an improvement of transmissivity of the lens.
- And the above improvements were noted to last for the duration of treatment.
Nac-C Plus™ Clinically Proven Ingredients
In combination with Can-C™ Eye Drops, Nac-C Plus™ Capsules contain specific antioxidants, and amino acids that have been clinically proven to help protect against common eye diseases such as cataracts,glaucoma and ARMD. Ingredients like N-Acetyl-Cysteine, L-Histidine, and L-Carnosine have all been shown to improve eyesight by boosting glutathione levels and functioning as powerful antioxidants to protect the lens of the eye from oxidative stress, keeping it more flexible and clear. Vitamin E and Zinc can also help prevent cataracts, glaucoma and other age-related vision problems.
Vitamin E (also known as alpha-tocopherol) is a fat-soluble antioxidant found in the membranes and lens fibers of the eye that has been shown to lessen the incidence of cataracts. It is thought to protect against cataracts by reducing the breakdown of lens lipids and stabilizing the cell membranes of the lens. Low Vitamin E levels have been linked to an increased risk of cataract formation in several studies(1), whereas higher Vitamin E consumption has been shown to protect against cataract formation and protect against the loss of trabecular meshwork cells in Glaucoma patients.(2)
Zinc is essential for maintaining healthy eyes and sharp eyesight. Zinc is concentrated in the “macula” of the retina, where it aids Vitamin A in the production of melanin, a pigment that protects the eye. Zinc deficiency has been linked to poor night vision; conversely, Zinc supplementation has been proven to delay the progression of age-related macular degeneration due to its role in maintaining a healthy macula.(1) In persons aged 65 to 74, supplementation with Zinc has been shown to reduce cataracts by as much as 36%.(2)
Boosts Glutathione which is particularly abundant in the lens of healthy eyes, and when it is reduced as a result of age or oxidative stress, cataracts can occur.(3,4) This is because glutathione protects lens flexibility and clarity by functioning as a strong antioxidant that protects proteins and enzymes from oxidative stress generated by free radicals.(5) This indicates that we need more glutathione to optimize eye health. N-Acetyl-Cysteine, taken orally, complements the glutathione sparing benefits of Can-C™ eye drops and boosts tissue glutathione levels in the eye.
L-Histidine works in combination with L-Carnosine and N-Acetylcarnosine to boost antioxidant activity in the eye, protecting it against cataract-causing damage.(6) Clinical trials have demonstrated that combining L-Histidine with other “natural imidazole-containing Peptidomimetics,” such as the ones mentioned above, improves the treatment’s efficacy and safety.(7,8)
Cataracts are often induced by oxidative stress, and L-Carnosine has been proven to have an antioxidant effect on a cataract-affected lens, improving DNA repair and preventing DNA strand breaks that can be caused by UV radiation.(10)
D-Pantethine, together with N-Acetyl-Carnosine and L-Carnosine, helps to repair cataracts, retinal degeneration, and diabetes-related ocular problems.(10)
L-Methionine is a precursor to the synthesis of other amino acids that support eye health, such as taurine, carnitine, and cysteine. L-Methionine is naturally created in the body following protein consumption, and can be found in a variety of foods, including egg whites, fish, chicken, and seaweed.
When paired with proper doses of B vitamins, L-Methionine can help reduce homocysteine levels, detoxifying the body and alleviating glaucoma, macular degeneration, and other retinal disorders.(11,12)
Nac-C Plus™ Capsules vs. Can-C + Capsules
Nac-C Plus™ is the only supplement on the market that still uses the original formula invented & tested by Dr Mark Babizhayev to provide optimal support for his Can-C™ eye drops.
Other products like “Can-C + capsules” have dropped integral ingredients such as N-Acetyl-Cysteine and L-Histidine from the formula despite the way that these ingredients synergistically integrate with the N-Acetyl-carnosine in Can-C™ eye drops. These specific ingredients in the original formula create heightened antioxidant activity and more effectively promote healing, repair, and protection from future damage.
If you’re looking for the exact eye health support regimen that Dr. Babizhayev himself recommended, the only choice is Can-C™ Eye Drops with Wise Choice Medicine’s Nac-C Plus™ capsules.
1. Olmedilla B, et al. Serum status of carotenoids and tocopherols in patients with age-related cataracts: a case-control study. J Nutr Health Aging 2002;6(1):66-8. https://pubmed.ncbi.nlm.nih.gov/11813087/
2. Robertson J M, et al. Vitamin E intake and risk of cataract in humans. Ann NY Acad Sci 1993; 372-82. https://pubmed.ncbi.nlm.nih.gov/2629606/
3. Blasiak J, et al. Zinc and Autophagy in Age-Related Macular Degeneration. Int J Mol Sci. 2020 Jul; 21(14): 4994. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404247/
4. Sperduto R D, et al. The Linxian cataract studies. Two nutrition intervention trials. Arch Ophthalmol. 1993 Sep;111(9):1246-53. https://pubmed.ncbi.nlm.nih.gov/8363468/
5. Kamei A. Glutathione levels of the human crystalline lens in aging and its antioxidant effect against the oxidation of lens proteins. Biol Pharm Bull 1993; 16(9); 170-5.
6. Oguchi M, et al. Glutathione and eye diseases. Ganka, 1970; 12: 125-32.
Giblin FJ. Glutathione: a vital lens antioxidant. J Ocul Pharmacol Ther 2000 Apr; 16(2):121-35.
7. N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treat-ment of human cataracts. Babizhayev MA, Deyev AI, Yermakova VN, Semiletov YA, Davydova NG, Kurysheva NI, Zhu-kotskii AV, Goldman IM. Peptides. 2001 Jun;22(6):979-94. PMID: 11390029 [PubMed – indexed for MEDLINE]
8. Photoprotector and antioxidant properties of histamine-containing peptidomimetics in the photooxi-dation of glycyltryptophan. Babizhayev MA, Lozovskaya EL, Makareyeva EN, Lul’kin YA, Sapezhinskii II. Biochemistry (Mosc). 1998 May;63(5):523-8. PMID: 9632886 [PubMed – indexed for MEDLINE]
9. Babizhayev MA, Guiotto A, Kasus-Jacobi A. N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications. J Drug Target. 2009;17(1):36-63.
10. Lou M F. Thiol regulation in the lens. J Ocul Pharmacol Ther 2000 Apr; 16(2):137-48. https://pubmed.ncbi.nlm.nih.gov/10803424/
11. Ghosh, S., Saha, M., Das, D. (2013). A study on plasma homocysteine level in age-related macular degeneration. Nepal J Ophthalmol, Jul-Dec;5(2):195-200.
12. Huang, P., Wang, F., et al. (2015). Homocysteine and the risk of age-related macular degeneration: a systematic review and meta-analysis. Sci Rep, Jul;21;5:10585.