"The clinical research of age-related cataracts in canines and rabbits has been conducted and the efficacy of using N-acetylcarnosine for cataract treatment was established. The striking results in canines and rabbits for both cataract reversal and prevention of lens opacities are clear."
Dr. Mark Babizhayev MA, PhDSenior Research Investigator - Innovative Vision Products
Many dog owners are using this product to effectively address their pet's cataract condition including veterinarians. Results in the Russian clinical trials were quite impressive with canines with no negative side affects. Dr. Babizhayev has also noted that Can-C appears to work even more effectively in canines than in humans. The dosage for animals has not yet been clearly defined so most pet owners are following the same dosage recommendation for humans and are applying 3 to 4 drops per affected eye daily. Remember also that the use of any unapproved drug for your animals should be discussed with your veterinarian. NOTE: Can-C™ is manufactured in a GMP certified, pharmaceutical facility which meets ISO 9001:2000 and ISO 13485:2003 standards for the design/formulation and manufacture of sterile contact lens solution and pharmaceutical solutions.
- N-a-Acetyl-Carnosine (NAC) 1.0% (approved by IVP)
- Glycerin (lubricant) 1.0%
- Carboxymethylcellulose sodium (lubricant) 0.3%
- Sterile Water (Ophthalmic Grade Isotonic Solution, pH 6.3 to 6.5) buffered with Potassium Phosphate Dibasic and Potassium Phosphate Monobasic
- Benzyl Alcohol (Preservative)
Animal Clinical Trials
Clinical Study Proves Can-C™ Safe and Effective “A new phenomenon of “melting snow” in only a few short weeks...
The testing of various anti-glycation agents over nearly a decade led a Russian research team to the development of n-alpha-acetylcarnosine as a delivery system for the natural eye anti-oxidant of L-carnosine. Once laboratory testing was passed, the next stage began to test the N-acetyl-carnosine Can-C eye-drops in the eyes of animals, (specifically canines and rabbits). These studies produced remarkably fast results in the improvement of clarity, glare sensitivity and overall vision for the animals involved. Furthermore, no serious side effects were noted and the beneficial affects were sustainable. Unsurprisingly, these positive results in animals led to the studies being continued in humans.
Control Study: Thirty dogs, (60 eyes) received topical application of Can-C 1% N-acetylcarnosine eye drop solution twice daily to cataracts.
- Improved visual behaviour of the animals within weeks of treatment.
- Cataract reversal starts from the periphery of the cataract followed by increased transparency of the lens.
- 96% of canine eyes treated with N-acetylcarnosine (Can-C) showed notable improvements.
- Dogs with both immature and ripe cataracts showed significant visual improvement.
Current Drug Therapy, 2006, Vol. 1, No. 1 107 – Excerpt from; “TREATMENT OF AGE- RELATED CATARACTS IN CANINES” - Mark Babizhayev MA PhD
Q. Are Can-C™ Eye Drops Really safe for animals?
A: Yes, N-Acetylcarnosine (Can-C™) eye drops have been researched in humans and in animals for over ten years and used for more than five years by thousands in Russia, China, Europe and the US without any side effects or complications. In fact the antioxidant properties of N-acetylcarnosine (Can-C™) apear to soothe and improve the overall health of dog eyes. Can-C™ is manufactured in a GMP (Good Manufacturing Procedures) facility per Dr. Mark Babizhayev's protocols and FDA guidelines, however only the lubricants (Carboxymethylcellulose sodium) and (glycerin) are approved by the FDA for ophthalmic use, Can-C is not yet FDA approved for the treatment of canine cataracts as the clinical trials have been conducted primarily in Russia over the last decade; therefore N-Acetylcarnosine (1%) is listed as an inactive ingredient on the label.
Q: I have been told that my dog is too small for cataract surgery. Can I use these cataract eye drops for him?
A. Can-C is a great solution for animals that do not have surgery as an option, and has been successfully used to treat the cataracts of domestic animals of all sizes from Chihuahuahs to the largest of breeds.
Q. What percentage of your customers actually reverse cataracts in their pets?
A: All customers who use the product per instruction will see improvements in their pet's cataract condition. The level of results can vary depending upon the maturity of the cataract at the outset of treatment. Additionally, injury induced dog cataracts and dog cataracts that result from steroid medications or diabetes can be more resistant and can take longer to respond to the product. Consistency of application is even more critical to success in the above mentioned scenarios and can mean the difference between minimal results and very good results. Again initial improvements generally present within the first 2-3 months. Optimal results are achieved with 6 - 12 months use. Once the optimal level of improvement has been reached, within 6 to 12 months time, it is advised to reduce the dose to 1 drop daily in the treated eye(s)
Q. What if the cataract has been there a long time and the dog is totally blind in that eye?
A: If the cataract is advanced to the point of total blindness the results are likely to be less than a 100% reversal with the use of Can-C. Cataracts at this stage often have hardened significantly and are more resistant to the good effects of Can-C™. Several points here; once cataracts have reached this advanced stage they become a constant irritant to the animal. The eyes can become very prone to infection as a result. Sadly, in many of these more severe cases, removal of the eye is advised. Can-C™ can reduce the risk of infection and even reduce these more mature cataracts in some instances with extended use. It is also important to note that the irritation can be significantly reduced as a result of Can-C™ being applied daily. As always it is advised to follow the advice of your veterinarian.
Q. Do the newer cataracts have a better success rate with this product?
A: In the human clinical trials, those who had cataracts for less than seven years experienced the most dramatic results. Those who had cataracts for seven to 15 years still received very good results. Those who had cataracts for more than 15 years experienced less dramatic improvements. This information tells us that the expected outcome is somewhat improved when treatment is initiated at the earlier stages of cataract development. However often with more mature cataracts it simply takes a little longer to achieve comparable results.
Q. What percentage of the cataract is removed in most cases?
A: The cataract is often fully reversed. With very mature cataract there is at least a very significant improvement in eye sight however complete reversal may not be possible depending upon the severity of the situation. Improvement in your pet's behavior and negotiation abilities is generally a good indicator of the desired result being achieved. Additionally you can actually see by looking into your pets eye when the cataract begins to get smaller and then smaller.
Q. How will I be able to tell if the product is working or not?
A: In animals, the cataract is very visible to our view. You can actually see the cataract shrinking over time with the use of this product. The cataract will generallyshrinkfromthe parameter inward and so your pet may have improvements in his/her peripheral vision first. The behavior of your pet is the best indicator however and with the return of sight and resulting improved ability to navigate their surroundings come improved confidence, mood and behavior. All of these indicators will clearly let you know that the product is working. At the end of 6 months if you are not sure you may want to visit your vet to determine if it is time to go to the maintenance dose of 1 drop daily or to continue a little longer with the reversal dose of 3-4 drops daily.
Q. Are there any potential side effects?
A: With this formula, utilized in 10 years of human and animal clinical trials, there have been no reported side effects or contra-indications, even when used everyday for up to 2 years. Generally use of this natural anti-oxidant formulation is soothing and improves the overall environment in the eye.
Q. Will my dogs cataract come back again after it has been reversed?
A: While it takes 3-4 drops daily over 3 - 12 months to reverse cataract it takes far less to prevent the re-growth of cataract. Therefore, once optimal level of reversal has been achieved only one drop daily will prevent the return of cataract. At this point the product will last far longer and so it will be far less expensive to maintain the health of your pets' eyes. Keep in mind that the same imbalance that allowed the cataract to form in the first place will still be present in your pet if you discontinue use of the product entirely. Unfortunately cataract will likely return, in a relatively short period of time, unless n-acetylcarnosine is being applied regularly to the eye.
Q. Will my dogs cataract come back again after it has been reversed?
A: Each box of Can-C contains two 5ml vials and each 5ml vial contains approximately 75 drops. When used to treat degenerative ocular conditions such as cataracts, one box will last approximately four to five weeks (3- 4 drops in each affected eye daily). When used as a preventive or maintenance measure, only one drop in each eye daily is needed, therefore one box of Can-C will last approximately 8 - 10 weeks.
Q. I am a vet is there a way for me to supply my patients with this product?
A: We offer professional discounts to physicians and veterinarians so that they may supply and monitor their patients. Please click here.
Q. Will the drops cause any discomfort or stinging in my dogs eyes?
A: Due to the optimal PH levels of this formulation there should be absolutely no stinging affects. Many owners inform us that their pets actually begin to act eager when it is time time to apply these soothing eyedrops. We can therefore assume that the dogs feel some releif with the application of Can-C™ on a regular basis.
Q. Is there a need to use a syringe for injecting the solution into my dogs eyes?
A: No, the drops are delivered directly from the vial without the need for syringes. You will want to keep your pet quiet while applying the drops and prevent him/her from shaking the drops out of the eye. Many pet owners find that it is easiest to lightly pinch the lower lid between thumb and forefinger creating a little pocket to apply the eye drop to, then lightly rest your hand over the face of your pet to keep him/her calm and to ensure full absorption.
Q. My dogs cataracts are the result of diabetes will Can-C™ help her?
A: While diabetic induced cataracts are often more aggressive and persistent, we have found that with the consistent application of just 4 drops a day, visible improvements generally present within 6-8 weeks, depending on how mature the cataract is. As the diabetes will continue to influence your dog it is possible that the cataracts can return, we recommend a daily drop in each eye to help prevent the return of the cataract once optimal results have been achieved.
Q. I saw another N-acetylcarnosine website and they said that the preservative Benzyl Alchohol is not good, is that true?
A: Definitely not true. Benzyl alcohol has long been utilized in ocular formulations as an FDA approved preservative. In the clinical trials conducted by Innovative Vision Products, five formulations were tested with varying preservatives and sources of NAC. In the end there was one that far surpassed all expectations and parameters. Interestingly it was the formulation with the preservative benzyl alcohol in combination with a unique source and purity level of NAC. Those who are claiming that benzyl alcohol causes burning do not understand the importance of the critical pH balance of ocular formulations. It is the incorrect balance of pH that can result in burning with some ocular formulations and not the preservative. We have absolutely no complaints of burning with our product in fact quite the opposight, which is why a large percentage of our customers use Can-C™ for dry eye syndrome, contact lens use and for eye strain relief. Remember it is this patented formulation that was tested over time and proven in a clinical controlled environment to reverse cataracts and resulted in no negative side affects. Unfortunately there are a few companies who continue to make attempts to circumvent Dr. Babizhayevs patent to avoid paying royalties. Not only are they not utilizing the proprietary source of NAC which is critical to theeffectiveness of this formulation, they have made changes to one or two of the excipient ingredients in their attempts to get around his patent. Again to be sure that you havepurchased the approved formula look for the following statement on the label of any product you have purchased. "Approved patented by Innovative Vision Products".